CD44 Antikörper (AA 3-10) (FITC)

Produktnummer ABIN118683

Dieser Anti-CD44 Antikörper ist ein Maus Monoklonal Antikörper zur Detektion von CD44 in FACS. Geeignet für Human.

Kurzübersicht für CD44 Antikörper (AA 3-10) (FITC) (ABIN118683)

Target: CD44

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD44 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Klon: VFF-7

Produktdetails anti-CD44 Antikörper (FITC)

Bindungsspezifität: AA 3-10

Spezifität: This antibody specifically recognises an epitope encoded by exon v6 on the variant portion of Human CD44.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Immunogen: Glutathione S Transferase (GST) fusion protein corresponding to the variable domains (v3 to v10) of Human CD44. Spleen cells from immunised BALB/c micewere fused with cells of the P3X63Ag8.653 myeloma cell line.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Use 10 μL to label 10^6 Cells/100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: Tris buffered saline containing 0.02 % Sodium Azide as preservative and 1 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CD44

Target: CD44

Andere Bezeichnung: CD44

Hintergrund: CD44 is the receptor for hyaluronic acid (HA). It mediates cell to cell and cell matrix interactions through its affinity for HA. Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. High protein heterogeneity due to several alternative splicing and post translational modification events. CD44R represents a heterogeneous group of CD44 variant isoforms expressed constitutively in epithelial cells and monocyte lineage cells and can be upregulated in activated leukocytes. CD44R, and in particular CD44v6 containing isoforms, may be involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to sites of inflammation. CD44v6 containing isoforms may be involved in tumor metastasis.Synonyms: CD44, CDw44, ECMR-III, Epican, Extracellular matrix receptor-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, LHR, MDU2, MDU3, MIC4, PGP-1, Phagocytic glycoprotein I

Gen-ID: 960

NCBI Accession: NP_000601

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling